ABCA2
Xenobiotic resistance
3 Mutations:
Coding,
N
Helicoverpa armigera
cotton bollworm - (species) D
Intraspecific
Mixed
Tay WT; Mahon RJ; Heckel DG ; et al. (2015)
Insect Resistance to Bacillus thuringiensis Toxin Cry2Ab Is Conferred by Mutations in an ABC Transpo[...]
Aminopeptidase N (APN)
Xenobiotic resistance
Coding,
Deletion
N
Helicoverpa armigera
cotton bollworm - (species) D
Experimental Evolution
Candidate Gene
Yang Y; Zhu YC; Ottea J ; et al. (2010)
Molecular characterization and RNA interference of three midgut aminopeptidase N isozymes from Bacil[...]
cadherin
Xenobiotic resistance
Coding,
Unknown
N
Helicoverpa armigera
cotton bollworm - (species) D
Intraspecific
Linkage Mapping
Xu X; Yu L; Wu Y (2005)
Disruption of a cadherin gene associated with resistance to Cry1Ac {delta}-endotoxin of Bacillus thu[...]
CYP337B3
Xenobiotic resistance
8 Mutations:
Coding,
Complex Change
Helicoverpa armigera
cotton bollworm - (species) D
Intraspecific
Mixed
4 References
Ha_BtR
Xenobiotic resistance
8 Mutations:
Coding,
N
Helicoverpa armigera
cotton bollworm - (species) D
Intraspecific
Mixed
3 References
para (kdr)
Xenobiotic resistance
2 Mutations:
Coding,
SNP
Helicoverpa armigera
cotton bollworm - (species) D
Intraspecific
Candidate Gene
Head DJ; McCaffery AR; Callaghan A (1998)
Novel mutations in the para-homologous sodium channel gene associated with phenotypic expression of [...]
tetraspanin
Xenobiotic resistance
Coding,
SNP
Helicoverpa armigera
cotton bollworm - (species) D
Intraspecific
Association Mapping
Jin L; Wang J; Guan F ; et al. (2018)
Dominant point mutation in a tetraspanin gene associated with field-evolved resistance of cotton bol[...]
ABCA2
Xenobiotic resistance
2 Mutations:
Coding,
Insertion
N
Trichoplusia ni
cabbage looper - (species) D
Intraspecific
Linkage Mapping
Yang X; Chen W; Song X ; et al. (2019)
Mutation of ABC transporter ABCA2 confers resistance to Bt toxin Cry2Ab in Trichoplusia ni.
ABCC2
Xenobiotic resistance
Unknown,
Unknown
Trichoplusia ni
cabbage looper - (species) D
Intraspecific
Linkage Mapping
Baxter SW; Badenes-Pérez FR; Morrison A ; et al. (2011)
Parallel evolution of Bacillus thuringiensis toxin resistance in lepidoptera.
ABCA2
Xenobiotic resistance
Coding,
Deletion
N
Helicoverpa punctigera
(species) D
Intraspecific
Candidate Gene
Tay WT; Mahon RJ; Heckel DG ; et al. (2015)
Insect Resistance to Bacillus thuringiensis Toxin Cry2Ab Is Conferred by Mutations in an ABC Transpo[...]
cadherin
Xenobiotic resistance
Coding,
SNP
N
Helicoverpa punctigera
(species) D
Intraspecific
Candidate Gene
Walsh T; James B; Chakroun M ; et al. (2018)
Isolating, characterising and identifying a Cry1Ac resistance mutation in field populations of Helic[...]
ABCA2
Xenobiotic resistance
Coding,
Insertion
N
Pectinophora gossypiella
pink bollworm - (species) D
Intraspecific
Candidate Gene
Mathew LG; Ponnuraj J; Mallappa B ; et al. (2018)
ABC transporter mis-splicing associated with resistance to Bt toxin Cry2Ab in laboratory- and field-[...]
cadherin
Xenobiotic resistance
7 Mutations:
Coding,
Pectinophora gossypiella
pink bollworm - (species) D
Intraspecific
Mixed
2 References
ABCC2
Xenobiotic resistance
Coding,
Insertion
Bombyx mori
domestic silkworm - (species) D
Domesticated
Linkage Mapping
Atsumi S; Miyamoto K; Yamamoto K ; et al. (2012)
Single amino acid mutation in an ATP-binding cassette transporter gene causes resistance to Bt toxin[...]
ABCC2
Xenobiotic resistance
Coding,
Deletion
N
Heliothis virescens
tobacco budworm - (species) D
Intraspecific
Linkage Mapping
Gahan LJ; Pauchet Y; Vogel H ; et al. (2010)
An ABC transporter mutation is correlated with insect resistance to Bacillus thuringiensis Cry1Ac to[...]
cadherin
Xenobiotic resistance
Coding,
Insertion
N
Heliothis virescens
tobacco budworm - (species) D
Intraspecific
Linkage Mapping
Gahan LJ; Gould F; Heckel DG (2001)
Identification of a gene associated with Bt resistance in Heliothis virescens.
para (kdr)
Xenobiotic resistance
3 Mutations:
Coding,
SNP
Heliothis virescens
tobacco budworm - (species) D
Intraspecific
Mixed
2 References
ABCC2
Xenobiotic resistance
Coding,
Deletion
N
Plutella xylostella
diamondback moth - (species) D
Intraspecific
Linkage Mapping
Baxter SW; Badenes-Pérez FR; Morrison A ; et al. (2011)
Parallel evolution of Bacillus thuringiensis toxin resistance in lepidoptera.
Acetylcholinesterase (Ace-1)
Xenobiotic resistance
3 Mutations:
Coding,
SNP
Plutella xylostella
diamondback moth - (species) D
Intraspecific
Candidate Gene
2 References
Chitin synthase 1 (CHS1)
Xenobiotic resistance
2 Mutations:
Coding,
SNP
Plutella xylostella
diamondback moth - (species)
Intraspecific
Candidate Gene
Douris V; Steinbach D; Panteleri R ; et al. (2016)
Resistance mutation conserved between insects and mites unravels the benzoylurea insecticide mode of[...]
CYP6BG1
Xenobiotic resistance
Cis-regulatory,
Unknown
Plutella xylostella
diamondback moth - (species) D
Intraspecific
Candidate Gene
Li X; Shan C; Li F ; et al. (2019)
Transcription factor FTZ-F1 and cis-acting elements mediate expression of CYP6BG1 conferring resista[...]
1 Additional References
FMO2
Xenobiotic resistance
Cis-regulatory,
Insertion
Plutella xylostella
diamondback moth - (species) D
Intraspecific
Candidate Gene
Mallott M; Hamm S; Troczka BJ ; et al. (2019)
A flavin-dependent monooxgenase confers resistance to chlorantraniliprole in the diamondback moth, P[...]
glutamate-gated chloride channel (GluCl)
Xenobiotic resistance
Coding,
SNP
Plutella xylostella
diamondback moth - (species) D
Intraspecific
Candidate Gene
Wang X; Wang R; Yang Y ; et al. (2016)
A point mutation in the glutamate-gated chloride channel of Plutella xylostella is associated with r[...]
MAP4K4
Xenobiotic resistance
Unknown,
Unknown
Plutella xylostella
diamondback moth - (species) D
Intraspecific
Linkage Mapping
Guo Z; Kang S; Chen D ; et al. (2015)
MAPK signaling pathway alters expression of midgut ALP and ABCC genes and causes resistance to Bacil[...]
nAChR
Xenobiotic resistance
3 Mutations:
Coding,
N
Plutella xylostella
diamondback moth - (species) D
Intraspecific
Mixed
3 References
para (kdr)
Xenobiotic resistance
6 Mutations:
Coding,
SNP
Plutella xylostella
diamondback moth - (species)
Intraspecific
Mixed
4 References
resistance to dieldrin
Xenobiotic resistance
Coding,
SNP
Plutella xylostella
diamondback moth - (species) D
Experimental Evolution
Candidate Gene
Li A; Yang Y; Wu S ; et al. (2006)
Investigation of resistance mechanisms to fipronil in diamondback moth (Lepidoptera: Plutellidae).
1 Additional References
RYR
Xenobiotic resistance
4 Mutations:
Coding,
Plutella xylostella
diamondback moth - (species) D
Intraspecific
Candidate Gene
3 References
ABCC2
Xenobiotic resistance
Coding,
Deletion
N
Spodoptera exigua
beet armyworm - (species) D
Intraspecific
Linkage Mapping
Park Y; González-Martínez RM; Navarro-Cerrillo G ; et al. (2014)
ABCC transporters mediate insect resistance to multiple Bt toxins revealed by bulk segregant analysi[...]
CYP321A8
Xenobiotic resistance
Cis-regulatory,
SNP
Spodoptera exigua
beet armyworm - (species) D
Intraspecific
Candidate Gene
Hu B; Huang H; Hu S ; et al. (2021)
Changes in both trans- and cis-regulatory elements mediate insecticide resistance in a lepidopteron [...]
CYP9A186
Xenobiotic resistance
Coding,
SNP
Spodoptera exigua
beet armyworm - (species) D
Intraspecific
Linkage Mapping
Zuo Y; Shi Y; Zhang F ; et al. (2021)
Genome mapping coupled with CRISPR gene editing reveals a P450 gene confers avermectin resistance in[...]
GSTe
Xenobiotic resistance
Coding,
SNP
Spodoptera exigua
beet armyworm - (species)
Intraspecific
Candidate Gene
Hilliou F; Chertemps T; Maïbèche M ; et al. (2021)
Resistance in the Genus Spodoptera: Key Insect Detoxification Genes.
1 Additional References
RYR
Xenobiotic resistance
Coding,
SNP
Spodoptera exigua
beet armyworm - (species) D
Intraspecific
Candidate Gene
Zuo YY; Ma HH; Lu WJ ; et al. (2020)
Identification of the ryanodine receptor mutation I4743M and its contribution to diamide insecticide[...]
2 Additional References
ABCC2
Xenobiotic resistance
2 Mutations:
Coding,
Complex Change
N
Spodoptera frugiperda
fall armyworm - (species) D
Intraspecific
Candidate Gene
2 References
CYP9A
Xenobiotic resistance
Gene Amplification,
Insertion
Spodoptera frugiperda
fall armyworm - (species)
Intraspecific
Association Mapping
Gimenez S; Abdelgaffar H; Goff GL ; et al. (2020)
Adaptation by copy number variation increases insecticide resistance in the fall armyworm.
GSTe
Xenobiotic resistance
Coding,
SNP
Spodoptera frugiperda
fall armyworm - (species)
Intraspecific
Candidate Gene
Hilliou F; Chertemps T; Maïbèche M ; et al. (2021)
Resistance in the Genus Spodoptera: Key Insect Detoxification Genes.
1 Additional References
Acetylcholinesterase (Ace-1)
Xenobiotic resistance
Coding,
SNP
Chilo suppressalis
striped riceborer - (species) D
Intraspecific
Candidate Gene
Jiang X; Qu M; Denholm I ; et al. (2009)
Mutation in acetylcholinesterase1 associated with triazophos resistance in rice stem borer, Chilo su[...]
RYR
Xenobiotic resistance
2 Mutations:
Coding,
SNP
Chilo suppressalis
striped riceborer - (species) D
Intraspecific
Candidate Gene
2 References
Acetylcholinesterase (Ace-1)
Xenobiotic resistance
Coding,
SNP
Cydia pomonella
codling moth - (species) D
Intraspecific
Candidate Gene
Cassanelli S; Reyes M; Rault M ; et al. (2006)
Acetylcholinesterase mutation in an insecticide-resistant population of the codling moth Cydia pomon[...]
1 Additional References
para (kdr)
Xenobiotic resistance
Coding,
SNP
Cydia pomonella
codling moth - (species) D
Intraspecific
Candidate Gene
Brun-Barale A; Bouvier JC; Pauron D ; et al. (2005)
Involvement of a sodium channel mutation in pyrethroid resistance in Cydia pomonella L, and developm[...]
1 Additional References
cadherin
Xenobiotic resistance
2 Mutations:
Coding,
Ostrinia furnacalis
Asian corn borer - (species) D
Intraspecific
Candidate Gene
Jin T; Chang X; Gatehouse AM ; et al. (2014)
Downregulation and mutation of a Cadherin gene associated with Cry1Ac resistance in the Asian Corn B[...]
1 Additional References
CYP337B3
Xenobiotic resistance
Coding,
Insertion
Helicoverpa zea
corn earworm - (species) D
Intraspecific
Candidate Gene
Walsh TK; Joussen N; Tian K ; et al. (2018)
Multiple recombination events between two cytochrome P450 loci contribute to global pyrethroid resis[...]
1 Additional References
para (kdr)
Xenobiotic resistance
5 Mutations:
Coding,
SNP
Helicoverpa zea
corn earworm - (species) D
Intraspecific
Linkage Mapping
Hopkins BW; Pietrantonio PV (2010)
The Helicoverpa zea (Boddie) (Lepidoptera: Noctuidae) voltage-gated sodium channel and mutations ass[...]
CYP6AB3
Xenobiotic resistance
Coding,
SNP
Depressaria pastinacella
(species)
Intraspecific
Candidate Gene
Mao W; Rupasinghe SG; Zangerl AR ; et al. (2007)
Allelic variation in the Depressaria pastinacella CYP6AB3 protein enhances metabolism of plant allel[...]
GSTe
Xenobiotic resistance
Coding,
SNP
Spodoptera litura
(species)
Intraspecific
Candidate Gene
Hilliou F; Chertemps T; Maïbèche M ; et al. (2021)
Resistance in the Genus Spodoptera: Key Insect Detoxification Genes.
1 Additional References
GSTe
Xenobiotic resistance
Coding,
SNP
Spodoptera littoralis
African cotton leafworm - (species)
Intraspecific
Candidate Gene
Hilliou F; Chertemps T; Maïbèche M ; et al. (2021)
Resistance in the Genus Spodoptera: Key Insect Detoxification Genes.
1 Additional References
Na/K-ATPase alpha-subunit
Xenobiotic resistance
4 Mutations:
Coding,
SNP
Danaus plexippus
monarch butterfly - (species) D
Danaus erippus
(species) D
Interspecific
Candidate Gene
Aardema ML; Zhen Y; Andolfatto P (2012)
The evolution of cardenolide-resistant forms of Na⁺,K⁺ -ATPase in Danainae butterflies.
3 Additional References
Na/K-ATPase alpha-subunit
Xenobiotic resistance
Coding,
SNP
Cycnia tenera
delicate cyncia - (species)
Lerina incarnata
(species)
Interspecific
Candidate Gene
Zhen Y; Aardema ML; Medina EM ; et al. (2012)
Parallel molecular evolution in an herbivore community.
1 Additional References
Na/K-ATPase alpha-subunit
Xenobiotic resistance
Coding,
SNP
Saucrobotys futilalis
dogbane pyralid moth - (species) D
Intergeneric or Higher
Candidate Gene
Ujvari B; Casewell NR; Sunagar K ; et al. (2015)
Widespread convergence in toxin resistance by predictable molecular evolution.
nAChR
Xenobiotic resistance
Coding,
SNP
Tuta absoluta
(species) D
Intraspecific
Candidate Gene
Silva WM; Berger M; Bass C ; et al. (2016)
Mutation (G275E) of the nicotinic acetylcholine receptor α6 subunit is associated with high levels o[...]
1 Additional References
para (kdr)
Xenobiotic resistance
5 Mutations:
Coding,
SNP
Tuta absoluta
(species) D
Intraspecific
Candidate Gene
2 References
RYR
Xenobiotic resistance
4 Mutations:
Coding,
SNP
Tuta absoluta
(species) D
Intraspecific
Candidate Gene
2 References
CYP6B1
Host plant specialization
Xenobiotic resistance
Coding,
SNP
Papilio polyxenes
black swallowtail - (species)
Interspecific
Candidate Gene
Li W; Schuler MA; Berenbaum MR (2003)
Diversification of furanocoumarin-metabolizing cytochrome P450 monooxygenases in two papilionids: Sp[...]
CYP6B4
Host plant specialization
Xenobiotic resistance
Coding,
SNP
Papilio glaucus
eastern tiger swallowtail - (species)
Intergeneric or Higher
Candidate Gene
Mao W; Schuler MA; Berenbaum MR (2007)
Cytochrome P450s in Papilio multicaudatus and the transition from oligophagy to polyphagy in the Pap[...]
FMO1
Host plant specialization
Xenobiotic resistance
Gene Amplification,
Complex Change
Tyria jacobaeae
cinnabar moth - (species)
Intergeneric or Higher
Candidate Gene
Sehlmeyer S; Wang L; Langel D ; et al. (2010)
Flavin-dependent monooxygenases as a detoxification mechanism in insects: new insights from the arct[...]